Dr. Karl E. Klose’s Laboratory

Research Interests

Dr. Karl E. Klose, Ph.D.
Professor of Microbiology
Director of South Texas Center for Emerging Infectious Diseases

Department of Biology
University of Texas at San Antonio (UTSA)
One UTSA Circle
San Antonio 78249 Texas
Phone: (210) 458-6140
Fax: (210) 458-4468
E-mail: Karl.Klose@utsa.edu

Ph.D. - Microbiology, University of California Berkeley 1993.
Postdoctoral Fellow - Harvard Medical School.

My lab is interested in bacterial pathogenesis- how bacteria cause disease. I have worked most extensively with Vibrio cholerae, the bacterium that causes cholera, and I am also researching Francisella tularensis, the bacterium that causes tularemia, or rabbit fever.
Cholera is found only where there are widespread problems with sanitation, so improving water and food supplies would eliminate the disease. Since that is unlikely to occur, a safe, cheap, effective vaccine is needed that would protect people. To design such a vaccine, my lab is addressing questions such as: How does V. cholerae know that it is in a human body and that that is the place to express genes necessary for its survival and disease potential? What are the genetic factors responsible for V. cholerae to cause disease? How does this organism persist in aquatic environments, which leads to human infection?
Very little is known about F. tularensis or about tularemia. It is a highly virulent organism and can easily be aerosolized, so it is classified by the Centers for Disease Control (CDC) as a Category A select agent with the highest potential to be used as a biological weapon. My lab is working to identify genetic factors responsible for F. tularensis to cause disease and to develop suitable vaccine candidates to protect against tularemia infection.

Visit the People page to learn about individual lab members' projects.

PubMed search for Dr. Karl E. Klose

Publications,- link to the PubMed: Klose KE  

South Texas Center for Emerging Infectious Diseases
Department of Biology
University of Texas at San Antonio