Publications

1. Jaffe, D.B., Aitken, P.G., and Nadler, J.V. The effects of cholecystokinin and cholecystokinin antagonists on synaptic function in the CA1 region of the hippocampal slice. Brain Res. 415:197–203, 1987.

2. Jaffe, D.B. and Johnston, D. The induction of LTP at hippocampal mossy fiber synapses follows a Hebbian rule. J. Neurophys. 64:948–960, 1990.

3. Aitken, P.G., Jaffe, D.B., and Nadler, J.V. Cholecystokinin and epileptogenesis in the hippocampal CA3 region. Exp. Brain Res. 20:103–106, 1991.

4. Aitken, P.G., Jaffe, D.B., and Nadler, J.V. Cholecystokinin blocks some effects of kainic acid in CA3 region of hippocampal slices. Peptides 12:127–129, 1991.

5. Jaffe, D.B., Johnston, D.B., Lasser-Ross, N., Lisman, J.E., Miyakawa, H., and Ross, W.N. The spread of Na+ spikes determines the pattern of dendritic Ca2+ entry into hippocampal neurons. Nature 357:244–246, 1992.

6. Jaffe, D.B., Ross, W.N., Lisman, J.E., Miyakawa, H., Lasser-Ross, N., and Johnston, D. A model of dendritic Ca2+ accumulation in hippocampal pyramidal neurons based on fluorescence imaging experiments. J. Neurophy. 71:1065–1077, 1994.

7. Miyakawa, H., Ross. W.N., Jaffe, D.B., J.C. Callaway, Lasser-Ross, N., Lisman, J.E., and Johnston, D., Synaptically activated increases in calcium concentration in the dendrites of hippocampal CA1 pyramidal cells are primarily due to voltage-gated Ca2+ channels. Neuron 9:1163–1173, 1992.

8. Spruston, N., Jaffe, D.B., Williams, S.H., and Johnston, D., Voltage- and Space-clamp errors associated with the measurement of electrotonically remote synaptic events. J. Neurophys. 70:781–802, 1993.

9. Jaffe, D.B. and Brown, T.H., Confocal imaging of dendritic Ca2+ transients in hippocampal brain slices during simultaneous current- and voltage-clamp recording.  Microscopy Res. and Tech.  29:279-289, 1994.

10. Jaffe, D.B., S.A. Fisher, and Brown, T.H., Confocal laser scanning microscopy reveals voltage-gated calcium signals within hippocampal dendritic spines.  J. Neurobiol. 25:220–233, 1994.

11. Jaffe, D.B. and Brown, T.H., Metabotropic glutamate receptor activation induces calcium waves in hippocampal neuron dendrites in vitro. J. Neurophys. 72:471–474, 1994.

12. Migliore, M., Cook, E.P., Jaffe, D.B., Turner, D.A., and Johnston, D. Computer simulations of morphometrically reconstructed CA3 hippocampal neurons J. Neurophys.73:1157-1168, 1995.

13. Jaffe, D.B. and Brown, T.H.  Calcium dynamics within thorny excrescences of CA3 neurons, J. Neurophys., 78:10-18, 1997.

14. Chitwood, R.A., Claiborne, B.J., and Jaffe, D.B., Modeling the passive properties of CA3 nonpyramidal neurons, In: Computational Neuroscience: Trends in Research 1997, J. Bower, editor, pp. 59-65, 1997.  

15. Chitwood, R.A. and Jaffe, D.B., Calcium-dependent spike frequency accommodation in hippocampal CA3 nonpyramidal neurons, J. Neurophys., 80:983-988, 1998.

16. Gulledge, A.T. and Jaffe, D.B., Dopamine decreases the excitability of layer V pyramidal neurons in rat prefrontal cortex., J. Neurosci., 18:9139-9151, 1998.

17. Chitwood, R.A., Hubbard, A., and Jaffe, D.B., Passive electrotonic properties of hippocampal CA3 interneurons, J. Physiol. (London), 515:743-756, 1999.

18. Jaffe, D.B. and Carnevale, N.T., Passive Normalization of Synaptic Integration Influenced by Dendritic Structure, J. Neurophys., 82:3268-3287, 1999.

19. Barea-Rodriguez, E.J., Rivera, D.T., Jaffe, D.B., and Martinez, Jr., J.L.  Protein synthesis inhibition blocks the induction of mossy fiber long-term potentiation in vivo.  J. Neurosci, 20:8528-8532, 2000.

20. Gulledge, A.T. and Jaffe, D.B., Multiple effects of dopamine on the excitability of layer V pyramidal neurons in rat prefrontal cortex, J. Neurophys. 86:585-595, 2001.

21. Hemond P. and Jaffe DB., Caloric restriction prevents aging-associated changes in spike-mediated Ca2+ accumulation and the slow afterhyperpolarization in hippocampal CA1 pyramidal neurons., Neuroscience, 135:413-420, 2005.

22. Zaika O, Lara L, Gamper N, Hilgemann DW, Jaffe DB, Shapiro MS., Angiotensin ii regulates neuronal excitability via pip2-dependent modulation of Kv7 (m-type) K+ channels, J. Physiol., 575:46-67, 2006.

23.  Gamper, N., Zaika, O., Li, Y., Martin, P., Hernandez, C., Perez, M., Wang, A.Y.C., Jaffe, D.B., and Shapiro, M.S., Oxidative modification of M-type potassium channels as the mechanism of cytoprotective neuronal silencing, EMBO Journal, 25:4996-5004, 2006.

24.  Dikkes, P, Jaffe, D., Chao, C., Hemond, P., Yoon, K., Guo, W. Lopez, M.F. Igf2 knockout mice are resistant to kainic acid-induced seizures and neurodegeneration.  Brain Res., 1175:85-90, 2007.

25.    Zaika, O., Tolstykh, G.P., Jaffe, D.B., and Shapiro, M.S., IP3-mediated Ca2+ signals direct purinergic P2Y-receptor regulation of neuronal ion channels, J. Neurosci., 27:8914-8926, 2007.

26.    Hemond, P., Epstein, D., Boley, A., Migliore, M., Ascoli, G., and Jaffe, D.B., Distinct classes of pyramidal cells exhibit mutually exclusive firing patterns in hippocampal area CA3b,  Hippocampus, 2008 (in press).

Reviews
   
1.    Johnston, D., Williams, S.H., Jaffe, D., and Gray, R., NMDA-receptor-independent long-term potentiation., Annu. Rev. Physiol. 54:489–505, 1992

2.    Ross, W.N., Miyakawa, H., Lev-Ram, V., Lasser-Ross, N., Lisman, J., Jaffe, D., and Johnston, D., Dendritic excitability in CNS neurons: Insights from dynamic calcium and sodium imaging in single cells., Jap. J. of Phys. 43 (Suppl. 1):S83–S89, 1993.

3.    Spruston, N., Jaffe, D.B., and Johnston, D., Dendritic attenuation of synaptic potentials and currents: the role of passive membrane properties. Trends. Neurosci. 17:161–166, 1994.

4.    Brown, T.H. and Jaffe, D.B., Calcium imaging in hippocampal neurons using confocal microscopy., Ann. N.Y. Acad. Sci., 747:313-24, 1994.

5.  Jaffe, D.B. and Gutierrez, R., Mossy fiber synaptic transmission: communication from the dentate gyrus to area CA3, Prog. Brain Res., 163:109-132, 2007.