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Faculty
Research Interests The hypothalamus regulates many vital physiological functions including eating and drinking, and body composition and weight. Research in my laboratory has emphasized the relevant hypothalamic transmitters involved and their interactions with psychoactive substances such as amphetamine and caffeine which affect eating and drinking. We have also determined the neural pathways over which certain types of peripheral sensory information associated with ingestion, due to stomach distension, for example, is transmitted and eventually reduces hypothalamic neuronal sensitivity which results in the cessation of eating and drinking. Results of additional studies demonstrate that stomach distension attenuates olfactory bulb neuronal activity which is related to alterations in the perception of food associated odors. These data have the potential to provide a basis for the reduction of excessive eating and drinking which results in obesity, a major cause of a variety of diseases. In addition, we have discovered that angiotensin II (AII), which is found in high concentrations in the hippocampus, inhibits the induction of dentated granule cell long-term potentiation (LTP). The inhibitory effect is mediated by the AT, receptor. The inhibition of LTP induction by ethanol and diazepam is also mediated by the AT, receptor and might be related to the anterograde amnesic effects of these two drugs. Recent Publications Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL, Kohno D, Uramura K, Sougawa H, Yada T, Wayner MJ, Sasaki K. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides. 2006 Nov;27(11):2738-49. Marks CA, Wayner MJ. Effects of sleep disruption on rat dentate granule cell LTP in vivo. Brain Res Bull. 2005 Jul 30;66(2):114-9. Ishibashi M, Takano S, Yanagida H, Takatsuna M, Nakajima K, Oomura Y, Wayner MJ, Sasaki K. Effects of orexins/hypocretins on neuronal activity in the paraventricular nucleus of the thalamus in rats in vitro. Peptides. 2005 Mar;26(3):471-81. Wayner MJ, Armstrong DL, Phelix CF, Oomura Y. Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo. Peptides. 2004 Jun;25(6):991-6. Wayner MJ, Armstrong DL, Phelix CF. Ethanol effects on dentate granule cell LTP. Neurotox Res. 2004;5(8):599-604. Aou S, Li XL, Li AJ, Oomura Y, Shiraishi T, Sasaki K, Imamura T, Wayner MJ. Orexin-A (hypocretin-1) impairs Morris water maze performance and CA1-Schaffer collateral long-term potentiation in rats. Neuroscience. 2003;119(4):1221-8. Wayner MJ. Craving for alcohol in the rat: adjunctive behavior and the lateral hypothalamus. Pharmacol Biochem Behav. 2002 Aug;73(1):27-43. Wayner MJ, Armstrong DL, Phelix CF, Wright JW, Harding JW. Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides. 2001 Sep;22(9):1403-14. Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW, Wright JW. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res. 2001 Apr 6;897(1-2):114-21. Shiraishi T, Oomura Y, Sasaki K, Wayner MJ. Effects of leptin and orexin-A on food intake and feeding related hypothalamic neurons. Physiol Behav. 2000 Nov 1-15;71(3-4):251-61. Wayner MJ, Tracy HA, Armstrong DL, Phelix CF. Air righting: role of the NMDA receptor channel and hippocampal LTP. Physiol Behav. 2000 Jun 1-15;69(4-5):505-10.
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Matthew
J. Wayner, Ph.D.