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Faculty
Clyde F. Phelix, Ph.D. Research Interests Emphasis is on extrahypothalmic influences on hypophysiotrophic and hypophyseal hormonal systems in CNS stress arcs. The majority of our anatomical work deals with chemical identification and morphological verification of brainstem and limbic afferents. Functional correlates involve neuroanatomical and pahrmacological inventigations of the role of neuronal pathways, between limbic-hypothalmic regions and brainstem cardiovascular regulatory centers in hemodynamic regulation during stress. The influences of environmental factors on gene expression in neuronal populations participating in the development of hypertension are a primary interest. Collaborations allow correlative investigations of chemoreceptive functions of area postrema, neurophysiological functions of transmitters in the hippocampus, and neurochemical effects of cocaine and other drugs of abuse on dopamine and serotonin in the basal forebrain. Recent Publications Seaman RL, Phelix CF. Acute effects of pulsed microwaves and 3-nitropropionic acid on neuronal ultrastructure in the rat caudate-putamen. Bioelectromagnetics. 2005 Feb;26(2):82-101. Wayner MJ, Armstrong DL, Phelix CF, Oomura Y. Orexin-A (Hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo. Peptides. 2004 Jun;25(6):991-6. Wayner MJ, Armstrong DL, Phelix CF. Ethanol effects on dentate granule cell LTP. Neurotox Res. 2004;5(8):599-604. Bailey SR, Polan JL, Morse B, Wetherold S, Villanueva-Vedia RE, Waggoner D, Phelix C, Barea-Rodriguez, E, Goswami N, Munoz O, Agrawal CM. Angiogenic bFGF expression from gas-plasma treated scaffolds. Cardiovasc Radiat Med. 2002 Jul-Dec;3(3-4):183-9. Polan JL, Morse B, Wetherold S, Villanueva-Vedia RE, Phelix C, Barea-Rodriguez, E, Waggoner D, Goswami N, Munoz O, Agrawal CM, Bailey SR. VEGF analysis induced by endothelialized gas-plasma treated D,L-PLA scaffolds. Cardiovasc Radiat Med. 2002 Jul-Dec;3(3-4):176-82. Wayner MJ, Armstrong DL, Phelix CF, Wright JW, Harding JW. Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides. 2001 Sep;22(9):1403-14. Wayner MJ, Tracy HA, Armstrong DL, Phelix CF. Air righting: role of the NMDA receptor channel and hippocampal LTP. Physiol Behav. 2000 Jun 1-15;69(4-5):505-10.
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