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Faculty
Ph.D., Marine Biology, Scripps Institution of
Oceanography, University of California Dr. Perry joined the UTSA faculty in 2006 from Case Western Reserve University where he was Professor of Pathology and Neurosciences and Chair of the Department of Pathology. He is also distinguished as one of the top 20 Alzheimer's disease researchers with over 600 publications, one of the top 100 most-cited scientists in Neuroscience & Behavior and one of the top 25 scientists in Free Radical research. He currently serves as Secretary-Treasurer and President-Elect for the American Association of Neuropathologists. He also serves as editor for several journals including Journal of Biomedicine and Biotechnology and Microscopy Research and Technique, is on the editorial board of many journals including American Journal of Pathology and Journal of Biological Chemistry, and is Editor-in-Chief of Journal of Alzheimer’s Disease. Research Interests Our studies are focused on the mechanism of formation and physiological consequences of the cytopathology of Alzheimer disease. We have shown that oxidative damage is the initial cytopathology in Alzheimer disease. We are working to determine the sequence of events leading to neuronal oxidative damage and the source of the increased oxygen radicals. Our current studies focus on (i) the mechanism for RNA-based redox metal binding; (ii) the consequences of RNA oxidation on protein synthesis rate and fidelity; (iii) the role of redox active metals in mediating prooxidant and antioxidant properties; (iv) the signal transduction pathways altered in Alzheimer disease that allow neurons to evade apoptosis; and (v) mechanism of phosphorylation control of oxidative damage to neurofilament proteins. Recent Publications Liu Q, Smith MA, Avila J, De Bernardis J, Kansal M, Takeda A, Zhu X, Nunomura A, Honda, K, Moreira PI, Oliveira CR, Santos MS, Shimohama S, Aliev G, de la Torre J, Ghanbari HA, Siedlak SL, Harris PLR, Sayre LM, Perry G (2005) Alzheimer-specific epitopes of tau represent lipid peroxidation induced conformations. Free Radic Biol Med 38, 746-754. Honda K, Smith MA, Baus D, Merrick WC, Tartakoff AM, Hattier T, Harris PL, Siedlak SL, Fujioka H, Liu Q, Moreira P, Miller F, Nunomura A, Shimohama S, Perry G (2005) Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron. J Biol Chem , J Biol Chem 280, 20978-20986. Obrenovich ME, Smith MA, Siedlak SL, Chen SG, de la Torre JC, Perry G, Aliev G (2006) Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Neurotox Res 10, 43-56. Casadesus G, Webber KM, Atwood CS, Pappolla MA, Perry G, Bowen RL, Smith MA (2006) Luteinizing hormone modulates cognition and amyloid-β deposition in Alzheimer APP transgenic mice. Biochim Biophys Acta 1762, 447-452. Nunomura A, Castellani RJ, Zhu X, Moreira PI, Perry G, Smith MA (2006) Involvement of oxidative stress in Alzheimer disease. J Neuropathol Exp Neurol 65, 631-641. Zhu X, Siedlak SL, Smith MA, Perry G, Chen SG (2006) LRKK2 protein is a component of Lewy bodies. Ann Neurol 60, 617-618. Zhu X, Avila J, Perry G, Smith MA (2007) Treating the lesions not the disease. Am J Pathol 170, 1457-1459. Thakur A, Siedlak SL, Perry G, Smith MA, Zhu X (2007) c-Jun phosphorylation in Alzheimer disease. J Neurosci Res, in press. Moreira PI, Siedlak SL, Santos MS, Oliveira CR, Fujioka H, Tabaton M, Nunomura A, Aliev G, Szweda LI, Smith MA, Zhu X, Perry G. (2007) Autophagocytosis of mitochondria is prominent in Alzheimer disease. J. Neuropathology and Exper. Neurology 66(6) in press.
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George Perry,
Ph.D.