Faculty

Edwin J. Barea-Rodriguez, Ph.D.
Associate Professor of Neurobiology
Office: BSB 3.03.38
Phone: (210) 458-5481
Edwin.Barea@utsa.edu

Ph.D., University of Southern Illinois, 1992.

Lab Page: http://www.utsa.edu/barealab/

Research Interests

The focus of my research is on the neurobiology of aging. The central hypothesis of my aging research program proposes that aged related impairments in cognition and synaptic plasticity share similar underlying cellular and molecular mechanisms. According to our model, oxidative stress causes impairment in neuronal excitability and maintenance of long-term potentiation (LTP), a form of synaptic plasticity believed to mediate learning and memory processes. The impairment in these physiological processes ultimately impairs spatial learning and memory in aged animals.

Recent Publications

Gonzalez L, Bustamante JJ, Barea-Rodriguez EJ, Martinez AO, Haro LS. 2-D native-PAGE/SDS-PAGE visualization of an oligomer's subunits: application to the analysis of IgG. Electrophoresis. 2006 May;27(10):2016-23.

Villarreal JS, Barea-Rodriguez EJ. ERK phosphorylation is required for retention of trace fear memory. Neurobiol Learn Mem. 2006 Jan;85(1):44-57.

Reddypalli S, Roll K, Lee HK, Lundell M, Barea-Rodriguez EJ, Wheeler EF. p75NTR-mediated signaling promotes the survival of myoblasts and influences muscle strength. J Cell Physiol. 2005 Sep;204(3):819-29.

Chirwa S, Aduonum A, Pizarro J, Reasor J, Kawai Y, Gonzalez M, McAdory BS, Onaivi E, Barea-Rodriguez EJ. Dopaminergic DA1 signaling couples growth-associated protein-43 and long-term potentiation in guinea pig hippocampus. Brain Res Bull. 2005 Jan 15;64(5):433-40.

Villarreal JS, Dykes JR, Barea-Rodriguez EJ. Fischer 344 rats display age-related memory deficits in trace fear conditioning. Behav Neurosci. 2004 Dec;118(6):1166-75.

Thompson KJ, Mata ML, Orfila JE, Barea-Rodriguez EJ, Martinez JL Jr. Metabotropic glutamate receptor antagonist AIDA blocks induction of mossy fiber-CA3 LTP in vivo. J Neurophysiol. 2005 May;93(5):2668-73.

Meilandt WJ, Barea-Rodriguez EJ, Harvey SA, Martinez JL Jr.Role of hippocampal CA3 mu-opioid receptors in spatial learning and memory. J Neurosci. 2004 Mar 24;24(12):2953-62.

Dieguez D Jr, Barea-Rodriguez EJ. Aging impairs the late phase of long-term potentiation at the medial perforant path-CA3 synapse in awake rats. Synapse. 2004 Apr;52(1):53-61.

Pizarro JM, Haro LS, Barea-Rodriguez EJ. Learning associated increase in heat shock cognate 70 mRNA and protein expression. Neurobiol Learn Mem. 2003 Mar;79(2):142-51.

Villarreal JS, Gonzalez-Lima F, Berndt J, Barea-Rodriguez EJ. Water maze training in aged rats: effects on brain metabolic capacity and behavior. Brain Res. 2002 Jun 7;939(1-2):43-51.

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