Dr. Richard LeBaron
My interests are to understand how cells’ microenvironment contributes to disease progression. Changes in the microenvironment in the human body are defined, at least in part, by molecules of the extracellular matrix (ECM) and ECM interactions with cell surface signaling receptors called integrins. Our recombinant protein technology has identified roles of ECM interaction on integrins in cell adhesion, migration, and cell death by apoptosis in disease states such as degenerative articular joint disease, diabetes, and cancer. Understating the complex relationship of ECM activation of cellular signaling pathways in diseased and healthy tissues is expected to provide opportunities for novel drug design and patient treatments.
Phelix, C.F., B. Watson, R.G. LeBaron, G. Villareal and D. Roberson, Transcriptome to Reactome Deterministic Modeling: Valadiation of in silco simulations of transforming growth factor-β1 signaling in MG63 osteosarcoma cells. IEEE Xplore, 2011. Accepted.
Phelix, C., R.G. LeBaron, G. Perry, R. Villanueva, G. Villareal, S. Siedlak and X. Zhu, In vivo and In Silico Evidence: Hippocampal Cholesterol Metabolism Decreases with Aging and Increases with Alzheimer’s Disease. Proceedings of the 2011 11th IEEE International Conference on Data Mining, 2011. (accepted).
Bauereis, B., W.E. Haskins, R.G. LeBaron and R. Renthal, Proteomic insights into the protective mechanisms of an in vitro oxidative stress model of early stage Parkinson's disease. Neurosci Lett, 2011. 488(1): p. 1-6.
Ghosh, S., L. Albitar, R. LeBaron, W.R. Welch, G. Samimi, M.J. Birrer, R.S. Berkowitz and S.C. Mok, Up-regulation of stromal versican expression in advanced stage serous ovarian cancer. Gynecol Oncol, 2010. 119(1): p. 114-20.
Zamilpa, R., R. Rupaimoole, C.F. Phelix, M. Somaraki-Cormier, W. Haskins, R. Asmis and R.G. LeBaron, C-terminal fragment of transforming growth factor beta-induced protein (TGFBIp) is required for apoptosis in human osteosarcoma cells. Matrix Biol, 2009. 28(6): p. 347-53.
True, L.D., S. Hawley, T.H. Norwood, K.R. Braun, S.P. Evanko, C.K. Chan, R.C. LeBaron and T.N. Wight, The accumulation of versican in the nodules of benign prostatic hyperplasia. Prostate, 2009. 69(2): p. 149-58.
Qiao, M., Q. Zhao, C.F. Lee, L.R. Tannock, E.J. Smart, R.G. LeBaron, C.F. Phelix, Y. Rangel and R. Asmis, Thiol oxidative stress induced by metabolic disorders amplifies macrophage chemotactic responses and accelerates atherogenesis and kidney injury in LDL receptor-deficient mice. Arterioscler Thromb Vasc Biol, 2009. 29(11): p. 1779-86.