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Dr. Floyd Wormley

Dr. Floyd Wormley

Associate Professor


Research Profile


Research Interests

Dr. Wormley’s studies host-fungal interactions  at mucosal tissues, vaginal and pulmonary, for the purpose of developing novel immune therapies and/or vaccines to treat and/or prevent fungal infections.  He currently is a standing member of the AIDS-Associated Opportunistic Infections and Cancer (AOIC) NIH study section, a member of the Committee on Microbiological Issues Impacting Minorities for the American Society for Microbiology (ASM),  the San Antonio Center for Medical Mycology, the South Texas Center for Emerging Infectious Diseases (STCEID) and the Medical Mycological Society of the Americas (MMSA).


Recent Publications

S Ravi, C Pierce, C Witt, and FL Wormley Jr. (2009). Biofilm formation by Cryptococcus neoformans under distinct environmental conditions.  Mycopathologia. (6):  307-14.

M Young, S Macias, D Thomas, FL Wormley, Jr. (2009). A proteomic-based approach for the identification of immunodominant Cryptococcus neoformans proteins. Proteomics. 9(9):2578-88.

K Wozniak, S Macias, S Ravi, M Young, C Steele, and FL Wormley Jr. (2009) Insights into the mechanisms of protective immunity against Cryptococcus neoformans infection using a mouse model of pulmonary cryptococcosis. PLOS One. 4(9): e6854.

S. Hardison, S. Ravi, M. Young, K. Wozniak, F. L. Wormley Jr. (2010) Induction of classical macrophage activation during experimental pulmonary cryptococcosis. American Journal of Pathology. 176(2):774-85.

S Hardison, K Wozniak, JK Kolls, FL Wormley Jr. (2010) IL-17 is not required for classical macrophage activation in a pulmonary mouse model of Cryptococcus neoformans infection. Infection and Immunity. 78(12):5341-51.

K Wozniak, S Hardison, JK Kolls, FL Wormley Jr. (2011) Role of IL-17A on resolution of pulmonary C. neoformans infection. PLoS ONE 6(2): e17204.

K Wozniak, M Young, FL Wormley, Jr. (2011) Protective immunity against experimental pulmonary cryptococcosis in T cell depleted mice. Clinical and Vaccine Immunology 18(5):717-23.

AK Chaturvedi, AL Lazzell, SP Saville, FL Wormley Jr., C Monteagudo, JL Lopez-Ribot, (2011) Validation of the tetracycline regulatable gene expression system for the study of the pathogenesis of infectious disease. PLoS ONE. 6(5):e20449.

CJ Walraven, SA Lee, SE Hardison, F Wormley, SR Lockhart, JR Harris, A Fothergill, B Wickes, J Gober-Wilcox, L Massie, TS N.l Ku, C Firactive, W Meyer, W Gerstein. (2011) Fatal disseminated Cryptococcus gattii infection in New Mexico. PLoS ONE 6(12): e28625.

SE Hardison, G Herrera, M L Young, KL Wozniak, and FL Wormley Jr., (2012) Protective immunity against pulmonary cryptococcosis is associated with STAT1 mediated classical macrophage activation. (Under Revision – Journal of Immunology).

J Yano, JK Kolls,  KI Happel,  FL Wormley,  KL Wozniak,  PL Fidel. (2012) The acute neutrophil response mediated by S100 alarmins during vaginal Candida infections is independent of the Th17-pathway (Under Review – PloS One).

C. Hole, H Bui, SM Levitz, FL Wormley Jr., and KL Wozniak. (2012) Mechanisms of Dendritic Cell Lyososomal Killing of Cryptococcus.  (Submitted – Scientific Reports).

K Wozniak, JK. Kolls, FL Wormley, Jr. (2012) Depletion of neutrophils in a protective model of pulmonary cryptococcosis results in increased IL-17A production by gamma/delta T cells. (Submitted – Mucosal Immunology).

AK Chaturvedi, FL Wormley Jr., (2012) Evaluation of protein fractions that induce protective immune responses against pulmonary C. neoformans infection.  (Under preparation).