Dr. Charles Wilson
We study the circuitry and neurons of the basal ganglia, with the goal of understanding the computational function of these structures at the cellular level, and their dysfunction in diseases, especially Parkinson’s Disease. Our experiments are focused on the ionic mechanisms that endow each cell type with its characteristic responses to synaptic input, the patterns of connectivity that deliver specific inputs to each cell, and the dynamics that arise from the combination of these.
Lobb, C.J., Wilson, C.J. and Paladini, C.A. (2010) A dynamic role for GABA receptors on the firing pattern of midbrain dopaminergic neurons. J. Neurophysiol. 104:403-413.
Dodla, R. and Wilson, C.J. (2010) Quantification of clustering in joint interspike interval scattergrams of spike trains. Biophys. J. 98:2535-2543.
Dodla, R. and Wilson, C.J. (2010) Coherence resonance due to transient thresholds in excitable systems. Phys. Rev. E 82:021105.
Farries, M.A., Kita, H. and Wilson, C.J. (2010) Dynamic spike threshold and zero membrane slope conductance shape the response of subthalamic neurons to cortical input. J. Neurosci. 30:13180-13191.
Goldberg J.A. and Wilson, C.J. (2010) The cholinergic interneurons of the striatum: Intrinsic properties underlie multiple discharge patterns. Handbook of Basal Ganglia Structure and Function, (H. Steiner and K.Y. Tseng, eds) Academic Press, pp. 133-149.
Wilson, C.J. (2010) Subthalamo-pallidal circuit. In: Handbook of Brain Microcircuits, (G Shepherd and S. Grillner, eds), Oxford University Press, pp. 127-134.
Lobb, C.J., Wilson, C.J. and Paladini, C.A. (2011) High-frequency, short-latency disinhibition bursting of midbrain dopaminergic neurons. J. Neurophysiol. 105:2501-2511.
Lobb, C.J., Troyer, T.W., Wilson, C.J., and Paladini, C.A. (2011) Disinhibition bursting of dopaminergic neurons. Frontiers in Systems Neuroscience 5:25.
Wilson, C.J., Beverlin, B. II, and Netoff, T. (2011) Chaotic desynchronization as the therapeutic mechanism of deep brain stimulation. Frontiers in Systems Neuroscience. 5:50.
Wilson, C.J. and Bevan, M.D. (2011) Intrinsic dynamics and synaptic inputs control the activity patterns of subthalamic nucleus neuron in health and in Parkinson's disease. Neuroscience 198:54-68.
Polhamus DG, Wilson CJ, Paladini CA. (2011) PRC Estimation with Varying Width Intervals. In: Phase Response Curves in Neuroscience: Theory, Experiment and Analysis. In: Neuroscience. Ed. N.W. Schultheiss, A. A. Prince, and R. J. Butera (eds). Springer, pp. 163-178.
Sciamanna G. and Wilson C.J. (2011) The ionic mechanism of gamma resonance in striatal fast-spiking neurons. J. Neurophysiol. 106:2936-2949.
Beatty J.A., Sullivan, M.A., Morikawa, H. and Wilson C.J. (2012) Complex autonomous firing patterns of striatal low-threshold spike interneurons. J. Neurophysiol. (in press).
Farries, M.A. and Wilson, C.J. (2012) Phase response curves of subthalamic neurons measured with synaptic input and current injection. J. Neurophysiol. (in press)
Farries, M.A. and Wilson, C.J. (2012) Biophysical basis of the phase response curve of subthalamic neurons. J. Neurophysiol. (in press).